Table 1.
Factors associated with outcomes in multivariate analysis in the whole group (N = 1,051).
| Variable | OS | EFS | CIR |
|---|---|---|---|
| Multivariate (p) HR (95% CI) |
Multivariate (p) HR (95% CI) |
Multivariate (p) HR (95% CI) |
|
| Age (1–10 years) | 0.032 0.709 (0.518–0.971) |
0.019 0.715 (0.540–0.945) |
0.054 0.728 (0.527–1.005) |
| WBC < 50 × 109/L | 0.431 0.861 (0.593–1.250) |
0.313 0.841 (0.624–1.177) |
0.190 0.791 (0.556–1.125) |
| Immunophenotype(T) | <0.001 2.017 (1.365–2.982) |
0.008 1.637 (1.135–2.361) |
0.100 1.409 (0.935–2.123) |
| Day 33 MRD ≥ 0.1% | 0.164 1.353 (0.884–2.070) |
0.016 1.599 (1.093–2.339) |
0.150 1.372 (0.894–2.106) |
| Week 12 MRD ≥ 0.01% | 0.589 1.148 (0.696–1.893) |
0.452 1.190 (0.756–1.873) |
0.230 1.358 (0.8221–2.248) |
| Re-emergent MRD | <0.001 6.135 (4.367–8.621) |
<0.001 5.848 (4.329–7.874) |
<0.001 7.476 (5.405–10.309) |
| Risk group (high-risk) | 0.001 1.795 (1.279–2.518) |
0.028 1.392 (1.037–1.868) |
0.120 1.289 (0.939–1.770) |
MRD, minimal residual disease; WBC, white blood count; HR, hazards ratio; CI, confidence interval; EFS, event-free survival; OS, overall survival; CIR, cumulative incidence of relapse.