Table 2.

Characteristics of patients with MRD-negative (n=880) and MRD-re-emergent (n=150).

Variables	MRD-re-emergent		MRD-negative		p
	N	%	N	%
Sex					0.997
Male	91	60.6	534	60.6
Female	59	39.3	346	39.3
Age(years)					0.362
<1	2	1.3	9	1.0
1–10	93	62.0	598	67.9
≥10	55	36.3	273	31.0
Initial WBC (109/L)					0.001
<50	102	68.0	705	80.1
≥50	48	32.0	175	19.8
Immunophenotype					0.029
Precursor B	122	81.3	773	87.8
T	28	18.6	107	12.1
Molecular subtype					0.538
TCF3-PBX1	9	6.0	54	6.1
BCR-ABL1	9	6.0	62	7.0
ETV6-RUNX1	13	8.6	143	16.2
KMT2A-r	4	2.6	27	3.0
Hyper-diploidy>50					0.830
Yes	23	15.3	129	14.6
No	127	84.6	751	85.4
Day 33 remission					0.014
Yes	144	96.0	871	98.9
No	6	4.0	9	1.0
Day 33 MRD					<0.001
<0.01%	81	54.0	651	73.9
0.01%–0.1%	17	11.3	81	9.2
0.1%–1%	29	19.3	73	8.2
≥1%	21	14.0	63	7.1
Week 12 MRD					<0.001
<0.01%	126	84.0	829	94.2
0.01%–0.1%	10	6.6	22	2.5
≥0.1%	14	9.3	29	3.2
Risk group					<0.001
SR	20	13.3	301	34.2
IR	88	58.6	417	47.3
HR	42	28.0	162	18.4

MRD, minimal residual disease; WBC, white blood count; SR, standard risk; IR, intermediate risk; HR, high risk.