TABLE 1.
The results of KEGG enrichment analysis.
| Group | Pathway | Pathway name | KEGG level 1 | KEGG level 2 |
| Control group vs. mild DR group | ko99984 | Nucleotide | Not included in pathway or BRITE | Unclassified: metabolism |
| ko00965 | Betalain biosynthesis | Metabolism | Biosynthesis of other secondary metabolites | |
| ko04614 | Renin-angiotensin system | Organismal Systems | Endocrine system | |
| ko00240 | Pyrimidine metabolism | Metabolism | Nucleotide metabolism | |
| ko04622 | RIG-I–like receptor signaling pathway | Organismal Systems | Immune system | |
| ko00910 | Nitrogen metabolism | Metabolism | Energy metabolism | |
| Mild DR group vs. excessive DR group | ko00010 | Glycolysis/gluconeogenesis | Metabolism | Carbohydrate metabolism |
| ko00750 | Vitamin B6 metabolism | Metabolism | Metabolism of cofactors and vitamins | |
| ko00520 | Amino sugar and nucleotide sugar metabolism | Metabolism | Carbohydrate metabolism | |
| ko00350 | Tyrosine metabolism | Metabolism | Amino acid metabolism | |
| ko00340 | Histidine metabolism | Metabolism | Amino acid metabolism | |
| ko99997 | Function | Not included in pathway or BRITE | Poorly characterized | |
| ko00780 | Biotin metabolism | Metabolism | Metabolism of cofactors and vitamins | |
| ko99976 | Replication | Not included in pathway or BRITE | Unclassified: gene□c information processing | |
| Control group vs. excessive DR group | ko00760 | Nicotinate and nicotinamide metabolism | Metabolism | Metabolism of cofactors and vitamins |
| ko00590 | Arachidonic acid metabolism | Metabolism | Lipid metabolism | |
| ko04918 | Thyroid hormone synthesis | Organismal Systems | Endocrine system | |
| ko05133 | Pertussis | Diseases | Infectious diseases: bacterial | |
| ko00523 | Polyketide sugar unit biosynthesis | Metabolism | Metabolism of terpenoids and polyketides | |
| ko00520 | Amino sugar and nucleotide sugar metabolism | Metabolism | Carbohydrate metabolism | |
| ko00521 | Streptomycin biosynthesis | Metabolism | Biosynthesis of other secondary metabolites | |
| ko00051 | Fructose and mannose metabolism | Metabolism | Carbohydrate metabolism | |
| ko00480 | Glutathione metabolism | Metabolism | Metabolism of other amino acids | |
| ko00720 | Carbon fixation pathways in prokaryotes | Metabolism | Energy metabolism | |
| ko00020 | Citrate cycle (TCA cycle) | Metabolism | Carbohydrate metabolism |
DR, dietary restriction; KO, KEGG Orthology.