Figure 3.

Rodent models of bipolar disorder exhibit reduced baseline neural circuit spectral power and coherence. Graphical summary of preclinical investigations demonstrating neural circuit disruptions induced by cannabinoid exposure in rodents used to model bipolar disorder. Rodents modeling bipolar disorder exhibit reduced baseline PFC and HIP spectral power, and reduced baseline NAc coherence. CLOCKΔ19, CLOCKΔ19 genetic mouse model of bipolar disorder; DAT-KO, DAT-KO genetic mouse model of bipolar disorder; HIP, hippocampus; NAc, nucleus accumbens; PFC, prefrontal cortex/prelimbic cortex. Green: Increase; Red: Decrease.