Figure 4.

Cannabinoid exposure disrupts neural circuit activity differently depending on administration route and dose, as well as the chosen cannabinoid. Graphical summary of preclinical investigations demonstrating neural circuit disruptions induced by cannabinoid exposure in healthy rodents. THC exposure increases neuronal firing rates in the PFC, HIP and VTA after i.p. injection or infusion, enhances spectral power after i.p. injection and suppresses spectral power after i.v. injection or vapor exposure, and suppresses PFC and HIP coherence after vapor exposure. WIN-55 exposure suppresses HIP and EC coherence after i.v. exposure. Studies showing no effect of cannabinoid exposure were not included. CP-55, CP-55940; EC, entorhinal cortex; HIP, hippocampus; PFC, prefrontal cortex/prelimbic cortex; VTA, ventral tegmental area. Green: Increase; Red: Decrease.