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. 2021 Feb 5;10:593293. doi: 10.3389/fonc.2020.593293

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Copyright © 2021 Su, Li, Zhang, Zhang, Shen and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High expression of DDX11 is correlated with poor prognosis in HCC. (A, B) Patients with HCC in TCGA cohort were divided into DDX11^high and DDX11^low, according to the median expression of DDX11 mRNA. Kaplan-Meier survival analyses (log-rank test) were conducted to indicate the clinical value of DDX11 mRNA in overall (A) and disease-free (B) survivals. (C, D) The implication of DDX11 protein expression was determined in patients with HCC in SYSUCC cohort. The median IHC score of DDX11 in HCC tissues was used as the cut-off value to separate cases into groups of DDX11^high and DDX11^low. (E) The impact of DDX11 mRNA on overall survival (OS) and disease-free survival (DFS) was tested in TCGA cancers (Mantel–Cox test). Significant p values were indicated by red and blue frames.