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. 2020 Mar 28;14(1):13–22. doi: 10.1007/s12265-020-09994-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Overview of novel strategies to target CD40(L). a Small molecule-mediated inhibition of CD40-TRAF6 interactions prevents inflammation but does not interfere with CD40-TRAF2/3/5-mediated immunity. b Antibody-mediated inhibition of the CD40L binding domain of Mac-1 prevents leukocyte recruitment. c Liposomal CD40 ASO reduce the expression of CD40 in monocytes and macrophages, but not in B cells