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. 2021 Feb 5;8:616489. doi: 10.3389/fmed.2021.616489

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Copyright © 2021 Li, Zhang, Sun, Liu, Manyande, Xu and Xiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scratching behaviors and Hematoxylin and eosin (H&E) staining of the neck skin in the control and DCP group. 0.1 ml 1% DCP dissolved in acetone or acetone was painted on the neck skin of the mice on day 1 and day 7 under conventional conditions. Scratching behaviors (A) were observed on day 9. Each value represents the mean ± SEM (n = 6–14 mice per group). H&E-stained sections from the neck skins treated with (B,C) acetone, (D,E) DCP. (B) A representative image of the neck skin from an acetone treated mouse. The skin was smooth and soft. (D) A representative image of the DCP application site from the DCP group. The skin manifested as rough and sclerotic, accompanied by scratches and scabs. ****P < 0.0001 vs. the mice treated with acetone. DCP, diphenylcyclopropenone.