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. 2021 Feb 18;11:4060. doi: 10.1038/s41598-021-83606-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cytotoxicity profile of L. squarrosulus peptide from 0.4 M NaCl fraction in human lung cancer and normal cells. The non-toxic concentration range of the peptide was determined in (a) human lung cancer H460, (c) dermal papilla DPCs, and (e) proximal renal HK-2 cells cultured with 0.4 M NaCl peptide (0–50 µg/mL) for 24 h via MTT viability assay. Costaining with Hoechst33342 and propidium iodide (PI) indicated no detectable apoptosis and necrosis (b) H460, (d) DPCs, and (f) HK-2 cells after treatment with 5 µg/mL of 0.4 M NaCl peptide for 24 h. Notably, no cell death was observed in DPCs and HK-2 cells at higher concentrations of the peptide while apoptosis cells were visually in Hoechst33342-stained H460 cells cultured with 10–50 µg/mL of 0.4 M NaCl peptide. Values are means of three independent experiments ± SD. *p < 0.05 versus non-treated control cells.