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. 2021 Feb 18;11:4060. doi: 10.1038/s41598-021-83606-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Peptide from Lentinus squarrosulus Mont. shows high safety prolife. Chemosensitizing effect of 0.4 M NaCl peptide from L. squarrosulus was presented in various human lung cancer cells including (a) H23, (c) H292 and (e) A549 cells. In comparison to cells with or without cisplatin treatment, peptide preincubation combined with cisplatin treatment augmented observed apoptosis cells which are characterized by condensed DNA/fragmented nuclei stained by bright blue fluorescence of Hoechst33342 in (b) H23, (d) H292 and (f) A549 cells. MTT assay revealed no alteration of cell viability in (g) human dermal papilla DPCs cells and (i) human proximal renal HK-2 cells after preculture with 5 µg/mL of 0.4 M NaCl peptide for 24 h following with treatment with 5 µM cisplatin for another 24 h. No detectable apoptosis and necrosis were noted via costaining with Hoechst33342/propidium iodide (PI) in all treatments of (h) DPCs and (j) HK-2 cells. Values are means of three independent experiments ± SD. *p < 0.05 versus non-treated control cells, ^#p < 0.05 versus the cells treated only with cisplatin.