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. 2021 Feb 18;11:4060. doi: 10.1038/s41598-021-83606-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Proposed regulatory machinery of chemosensitizing effect of peptide extracted from Lentinus squarrosulus on cisplatin-induced apoptosis in human lung cancer cells. The peptide enhances the suppressive activity of cisplatin on integrin-mediating survival which resultes in the downregulation of integrin and down-stream signaling proteins including p-FAK/FAK, p-Src/Src and p-Akt/Akt as well as activation of apoptosis mediated by overexpression of p53 which correlates with increased Bax and diminution of anti-apoptosis Mcl-1 and Bcl-2 proteins. The effects of the peptide and cisplatin at non-toxic concentrations is indicated by red and blue small arrows, respectively. Big pink arrows represent the augmented cytotoxicity of cisplatin after pretreatment of human lung cancer cells with 0.4 M NaCl fraction of L. squarrosulus peptides.