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. 2021 Feb 18;12:1122. doi: 10.1038/s41467-021-21458-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Three examples of cis-eQTLs only driven by interaction, rs12582553-IL26 (linear regression, t test, FDR_interaction = 0.046), rs337930-TRENL4 (linear regression, t test, FDR_interaction = 0.00046) and rs3808491-LY6D (linear regression, t test, FDR_interaction = 5.92e − 05). Top panel: X-axis indicates the genotypes of the eSNPs stratified by inflammation status. Y-axis indicates the scaled expression levels of the eGenes. Bottom panel: X-axis indicates the genotypes of the eSNPs in all samples combined. Y-axis indicates scaled expression levels of the eGenes. b Three inflammation-dependent immunoglobulin cis-eQTLs. Panels are similar to (a). c One example of cis-eQTL driven by both genotype and the interaction, rs6860700-C6 (linear regression, t test, FDR_interaction = 0.014; FDR_genotype < 2.26e − 16). Box plots show medians and the first and third quartiles (the 25th and 75th percentiles), respectively. The upper and lower whiskers extend the largest and smallest value no further than 1.5 × IQR (n = 280 samples). Source data are provided as a Source Data file.