Table 3.
Associations between thyroid-stimulating hormone (TSH) statuses combined with thyroid peroxidase antibody (TPO Ab)+/− and the birth outcomes.
| N total | Caesarean section | Preterm birtha | Low birth weight | Small for gestational ageb | Large for gestational ageb | Neonatal hyperbilirubinemia | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N case (%) | OR(95%CI) | N case (%) | OR(95%CI) | N case (%) | OR(95%CI) | N case (%) b | OR(95%CI) | N case (%) b | OR(95%CI) | N case (%) | OR(95%CI) | ||
| 0.1≤TSH<2.5 mIU/L and TPO Ab− | 6225 | 3142 (45.4) |
1.00 | 421 (6.1) | 1.00 | 382 (5.5) | 1.00 | 691 (10.8) |
1.00 | 497 (8.0) |
1.00 | 593 (8.6) |
1.00 |
| TSH<0.1 mIU/L and TPO Ab+/− | 144 | 80 (48.5) |
1.10 (0.79, 1.53) |
8 (4.8) | 0.75 (0.36, 1.54) |
12 (7.3) |
1.42 (0.71, 2.82) |
21 (14.0) |
1.45 (0.90, 2.34) |
15 (10.4) |
1.31 (0.73, 2.35) |
20 (12.1) |
1.47 (0.91, 2.37) |
| 0.1≤TSH<2.5 mIU/L and TPO Ab+ | 560 | 299 (47.6) |
1.01 (0.85, 1.20) |
36 (5.7) | 0.91 (0.64, 1.30) |
38 (6.1) | 1.17 (0.79, 1.75) |
68 (11.6) |
1.14 (0.87, 1.49) |
44 (7.9) |
0.94 (0.67, 1.34) |
56 (8.9) |
1.05 (0.79, 1.40) |
| 2.5≤TSH ≤ 4.0 mIU/L and TPO Ab − | 863 | 408 (42.4) |
0.98 (0.85, 1.13) |
42 (4.4) | 0.73 (0.53, 1.02) |
38 (4.0) | 0.65 (0.43, 0.97)* |
99 (11.1) |
0.96 (0.76, 1.20) |
68 (7.9) |
1.09 (0.82, 1.44) |
69 (7.2) |
0.85 (0.66, 1.11) |
| 2.5≤TSH ≤ 4.0 mIU/L and TPO Ab+ | 121 | 64 (45.7) |
0.95 (0.67, 1.34) |
5 (3.6) | 0.58 (0.24, 1.43) |
5 (3.6) |
0.68 (0.25, 1.80) |
19 (14.7) |
1.52 (0.92, 2.52) |
11 (9.1) |
1.12 (0.58, 2.18) |
16 (11.4) | 1.39 (0.82, 2.36) |
| TSH>4.0 mIU/L and TPO Ab+/- | 30 | 79 (45.4) |
1.20 (0.87, 1.65) |
5 (2.9) | 0.46 (0.19, 1.14) |
12 (6.9) |
2.01 (1.05, 3.84)* |
21 (12.4) |
1.03 (0.64, 1.65) |
4 (2.6) |
0.41 (0.15, 1.17) |
19 (10.9) |
1.41 (0.87, 2.30) |
Logistic regression: adjusted for age, BMI, parity, gestational week, gestational week of measurement, neonatal gender, gestational diabetes mellitus. avariable of gestational week was excluded among the covariates in the analysis of PB. bsubjects with birthweight appropriate for gestational age served as the reference group. *P < 0.05.