Table 4.
Associations between clinical thyroid status and the birth outcomes.
| N total | Caesarean section | Preterm birtha | Low birth weight | Small for gestational ageb | Large for gestational ageb | Neonatal hyperbilirubinemia | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N case (%) | OR(95%CI) | N case (%) | OR(95%CI) | N case (%) | OR(95%CI) | N case (%) | OR(95%CI) | N case (%) | OR(95%CI) | N case (%) | OR(95%CI) | ||
| Euthyroidism and TPO Ab− | 7605 | 3423 (45.0) |
1.00 | 445 (5.9) |
1.00 | 403 (5.3) |
1.00 | 760 (10.8) |
1.00 | 549 (8.0) |
1.00 | 637 (8.4) |
1.00 |
| Euthyroidism and TPO Ab+ | 740 | 349 (47.2) |
1.00 (0.86, 1.18) |
40 (5.4) |
0.83 (0.54, 1.28) |
42 (5.7) |
1.12 (0.76, 1.64) |
85 (12.4) |
1.22 (0.95, 1.55) |
53 (8.1) |
0.98 (0.71, 1.34) |
71 (9.6) |
1.14 (0.88, 1.48) |
| Subclinical hypothyroidism and TPO Ab+/− | 215 | 98 (45.6) |
1.23 (0.93, 1.64) |
6 (2.8) |
0.73 (0.28, 1.88) |
14 (6.5) |
1.94 (1.06, 3.55)* |
27 (13.0) |
1.13 (0.75, 1.72) |
8 (4.3) |
0.71 (0.34, 1.49) |
22 (10.2) |
1.33 (0.85, 2.08) |
| Subclinical hyperthyroidism and TPO Ab +/− | 212 | 103 (48.6) |
1.15 (0.86, 1.53) |
10 (4.7) |
0.78 (0.36, 1.72) |
13 (6.1) |
1.38 (0.73, 2.59) |
26 (13.2) |
1.26 (0.83, 1.94) |
15 (8.1) |
1.07 (0.61, 1.88) |
23 (10.8) |
1.33 (0.86, 2.07) |
| Isolated hypothyroxinemia and TPO Ab +/- | 213 | 99 (46.5) |
1.04 (0.78, 1.38) |
16 (7.5) |
1.48 (0.77, 2.85) |
15 (7.0) |
1.50 (0.81, 2.77) |
21 (10.6) |
0.99 (0.62, 1.58) |
14 (7.3) |
0.91 (0.51, 1.62) |
20 (9.4) |
1.13 (0.70, 1.80) |
Logistic regression: adjusted for age, BMI, gestational week, neonatal gender. To concise the covariates, covariates including parity, gestational week of measurement, and gestational diabetes mellitus were excluded in the regression due to the lack of significance (P>0.05). avariable of gestational week was excluded among the covariates in the analysis of PB. bsubjects with birthweight appropriate for gestational age served as the reference group. *P < 0.05.