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. 2021 Jan 6;62:100017. doi: 10.1194/jlr.TR120000981

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© 2021 The Author

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 2 — Fatty acids and oxidized fatty acid products in control and diabetic retina. Control retina is enriched in omega-3 PUFA with lower levels of omega-6 PUFA (left panel). Diabetes shifts the balance between PUFA toward lower omega-3 PUFA and higher omega-6 PUFA (right panel). This leads to a change in composition of oxidized fatty acid products with a shift from omega-3 PUFA-derived proresolution products, resolvins and protectins, to omega-6 PUFA-derived proinflammatory monooxygenase (MOX), lipoxygenase (LOX), and COX oxidized lipid mediators. Hydrolysis of COX PUFA metabolites by soluble epoxide hydrolase gives rise to dihydro-FAs that further contribute to the pathogenesis of DR.