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. 2021 Feb 18;12:1142. doi: 10.1038/s41467-021-21476-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Representative images of RNAscope in situ hybridization of Hrh1 mRNA together with immunostaining of choline acetyltransferase (ChAT) in the NBM of BF for patients with schizophrenia and controls. The right panels are enlarged from the dotted box in the left panels. Left: scale bar, 30 μm. Right: scale bar, 10 μm. b–f Hrh1 mRNA expression in ChAT⁺ or ChAT⁻cells, ChAT expression, soma size, and density of ChAT⁺ cells in patients with schizophrenia and controls (n = 12 for controls, n = 11 for patients with schizophrenia having positive and negative symptoms, and n = 3 for patients with schizophrenia having positive symptoms). b Quantitative analysis of Hrh1 mRNA expression in ChAT⁺ cells of patients with schizophrenia and controls. c Quantitative analysis of Hrh1 mRNA expression in ChAT^- cells of patients with schizophrenia and controls. d Quantitative analysis of ChAT expression of ChAT⁺ cells in patients with schizophrenia and controls. e Quantitative analysis of soma size of ChAT⁺ cells in patients with schizophrenia and controls. f Quantitative analysis of density of ChAT⁺ cells in patients with schizophrenia and controls. All data are presented as mean ± s.e.m. and error bars represent s.e.m. *P ≤ 0.05, **P ≤ 0.01, ns nonsignificant. See also Supplementary Data 2 for further statistical information. Source data are provided as a Source Data file.