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. 2021 Feb 18;11:4184. doi: 10.1038/s41598-021-83669-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Electroretinogram recordings of P2X7-KO mice show a predominant reduction in the pSTR amplitude, without sign of rescue following acute IOP elevation. Representative waveforms of retinal responses measured at bright ((A), 2.07 log cd·s/m²) and dim ((B), − 5.31 to − 4.31 log cd·s/m²) luminous energies. Average amplitude of the pSTR (C) and nSTR (D) following sham (white bars) or elevated IOP (red bars) treatment. Average implicit time to the peak amplitude of the pSTR (E) or nSTR (F) following sham or elevated IOP treatment. The amplitude and implicit time of the pSTR was significantly reduced in eyes subject to elevated IOP. (G) The effect of IOP on pSTR and nSTR responses expressed as a percentage loss of the sham eye show no differences between P2X7-KO and WT. Numbers indicate the number of mice. **p < 0.01, ***p < 0.001; paired t-test (sham vs IOP).