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. 2021 Feb 18;11:4184. doi: 10.1038/s41598-021-83669-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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pMEA recordings of P2X7-KO mice demonstrate dysfunction of OFF-RGCs, without rescue, and additional dysfunction of ON-RGC following acute IOP elevation. (A) Spontaneous activity was increased in ON and ON–OFF RGCs and (B) light-elicited responses were reduced in ON- and OFF-RGCs following elevated IOP (red bars). (C) The latency to peak response was increased in OFF-RGCs following elevated IOP. Numbers indicate the number of cells recorded from n = 6 animals. (D–F) The spontaneous activity and light-elicited responses were averaged per retina and are presented per retina for ON- (D), OFF- (E) and ON–OFF (F) RGCs. Insets show the spontaneous rate of cells from sham and elevated IOP eyes. Both ON- and OFF-RGCs from the P2X7-KO mouse showed reduced light responsiveness following acute IOP elevation*p < 0.05, **p < 0.01, ****p < 0.0001; Mann–Whitney test (sham vs IOP).