Table 1.
Patient clinical and pathological characteristics.
| Pt ID | Age | Sex | Therapya | Rai stage | ZAP-70 | IGHV | Cytogenetic abnormalities | Ibrutinib resistance | BTK mutation | Proliferating fraction in untreated control |
|---|---|---|---|---|---|---|---|---|---|---|
| CCLL011 | 42 | M | T | 1 | Pos | UM | Trisomy 12 | No | No | 2.7 |
| CCLL015 | 56 | F | T | 1 | Pos | UM | Trisomy 12 | No | No | 36.2 |
| CCLL094 | 62 | F | NT | 1 | Neg | M | del(13q14.3) | No | No | 21.8 |
| CCLL189 | 60 | M | T | 4 | − | UM | del(13q14.3), del(11q22.3) | No | No | 60.8 |
| CCLL248 | 67 | F | NT | 3 | Neg | M | del(13q14.3) | No | No | 19.3 |
| CCLL292 | 77 | F | T | 4 | Neg | UM | del(13q14.3), del(17p) | No | No | 31.3 |
| CCLL306 | 68 | M | T | 3 | Pos | UM | Normal | No | No | 20.0 |
| CCLL320 | 65 | F | NT | 4 | N/A | UM | Normal | No | No | 15.9 |
| FCLL003 | 85 | F | T | N/A | N/A | UM | Normal | No | No | 62.5 |
| FCLL008 | 65 | F | T | 3 | N/A | UM | Complex, del(11q22.3), del(13q14.3) | No | No | 66.5 |
| FCLL009 | 87 | F | T | 1 | N/A | UM | Complex, del(11q22.3), del(13q14.3) | No | No | 89.7 |
| FCLL012 | 61 | M | NT | 0 | N/A | N/A | del(11q22.3), del(13q14.3) | No | No | 44.4 |
| FCLL016 | 56 | M | NT | 1 | N/A | M | del(13q14.3) | No | No | 87.0 |
| FCLL018 | 65 | M | NT | 0 | N/A | N/A | del(13q) | No | No | 3.1 |
| FCLL020 | 74 | M | NT | 1 | Neg | M | del(13q14.3) | No | No | 4.8 |
| SCLL025 | 53 | M | NT | 2 | Pos | UM | Normal | No | No | 18.5 |
| SCLL034 | 67 | M | NT | 0 | Pos | M | Normal | No | No | 55.6 |
| UCLL040 | 77 | M | T | 0 | Pos | N/A | del(11q22.3), trisomy 12 | No | No | 85.7 |
| UCLL046 | 36 | M | NT | 1 | N/A | M | Normal | No | No | 70.8 |
| UCLL047 | 64 | M | NT | 0 | Neg | UM | Trisomy 12 | No | No | 83.1 |
| UCLL053 | 45 | M | NT | N/A | Ind | M | del(13q14.3) | No | No | 51.5 |
| UCLL057 | 88 | F | T | 3 | N/A | UM | del(13q14.3) | No | No | 4.9 |
| UCLL058 | 40 | M | T | 2 | Ind | UM | del(13q14.3) | No | No | 6.2 |
| NCLL018 | 47 | M | T | 2 | Pos | UM | del(11q22.3), del(13q14.3) | Yes | BTKC481S | 82.9 |
| NCLL021 | 72 | M | T | 0 | N/A | UM | Trisomy 12 | Yes | No | 92.1 |
| UCLL011 | 57 | F | T | N/A | Pos | UM | del(17p) | Yes | BTKC481S | 65.8 |
| UCLL017 | 68 | M | T | N/A | Pos | UM | del(17p) | Yes | No | 15.3 |
| UCLL034 | 50 | M | T | 4 | Pos | UM | del(13q14.3) | Yes | BTKC481Y | 85.7 |
| UCLL035 | 64 | M | T | 2 | Pos | UM | del(11q22.3), del(13q14.3) | Yes | BTKC481S/Y | 87.9 |
| UCLL041 | 59 | M | T | N/A | Neg | UM | del(17p) | Yes | BTKC481F | 43.1 |
| UCLL052 | 56 | M | T | N/A | N/A | N/A | del(17p) | Yes | BTKC481S | 87.3 |
N/A information not available, Ind indeterminant, T treated, NT not treated.
aTreatment status at the time of sample collection.