Figure 1.

The crosstalk between phosphorylation and ubiquitination regulates related biological and pathological processes. In most cases, CRLs are prone to recognize and interact with those proteins with Ser/Thr rich degrons which have been phosphorylated, but sometimes, it will abrogate the interaction between substrates and CRLs when anyone of them is phosphorylated. The crosstalk between phosphorylation and ubiquitination regulates different biological processes including oxidative stresses, cell cycle, genomic stability and transcription factors activity, subsequently inducing various diseases, mainly cancers.