Table 1.

Summary of the crosstalk between phosphorylation and ubiquitination and its biological function when phosphorylation exits in substrates.

CRL	Substrate	Ubiquitinated site	Phosphorylated site	Kinase	How phosphorylation affects interaction between substrates and receptors	Biological function	Ref.
Cullin 1-based SCF E3 ligase	EXO1	Lys796	Ser714	ATR	Promotion	Preservation of genomic stability	27
Cullin 1-based SCF E3 ligase	RRM2	Lys796	Thr33	CDK	Promotion	Preservation of genomic stability	28
Cullin 1-based SCF E3 ligase	USP37	Lys11	Ser858	CDK2	Promotion	Regulation of cell cycle	29
Cullin 1-based FBX4 E3 ligase	TRF1	Lys194/240	Ser114	NEK7	Inhibition	Preservation of telomere chromatin integrity	30
Cullin 1-based FBXO11 E3 ligase	CDT2	Lys48	Thr464	CDK	Inhibition	Regulation of cell cycle and cell differentiation	31
Cullin 1-based FBXO31 E3 ligase	SNAIL1	Lys98/137/146	Ser6	GSK3β	Promotion	Tumor suppression	18
Cullin 1-based FBXO31 E3 ligase	Cyclin D1	Lys48	Thr286	CDK4	Promotion	Regulation of cell cycle	32
Cullin 1-based FBXO31 E3 ligase	MDM2	Lys36	Six sites	ATM	Promotion	Tumor suppression	33
Cullin 1-based FBW7 E3 ligase	XBP1	Lys236	Ser212/217	–	Promotion	Tumor suppression	34
Cullin 1-based KDM2B E3 ligase	c-Fos	Lys113	Ser374	EGF	Inhibition	Tumor promotion	35
Cullin 1-based FBXL3 E3 ligase	CRY1	Lys11/107/159/329/442/485	Ser588	DNA-PK	Inhibition	Regulation of transcription	35
Cullin 1-based FBXO3 E3 ligase	AIRE	–	Thr68/Ser156	DNA-PK	Promotion	Regulation of transcription	36
Cullin 2-based COMMD1 E3 ligase	RELA	–	Ser468	IκB	Promotion	Regulation of transcription	37
Cullin 2-based VHL E3 ligase	ID2	Lys12	Thr27	DYRK	Promotion	Tumor suppression	38
Cullin 3-based SPOP E3 ligase	ERG	–	–	CKI	Promotion	Tumor suppression	39
Cullin 3-based SPOP E3 ligase	SRC-3	Lys316	Ser101/102/860	CKIε/p38MAPK	Promotion	Tumor suppression	12
Cullin 3-based HIB E3 ligase	Ci/Gli	–	–	CK1	Inhibition	Regulation of Hedgehog signaling	23
Cullin 3-based SPOP E3 ligase	PDX1	–	Thr230/Ser231	CK2	Inhibition	Regulation of type 2 diabetes	40
Cullin 3-based KBTBD8 E3 ligase	TCOF1	–	–	CK2	Promotion	–	22
Cullin 3-based KBTBD8 E3 ligase	NOLC1	Lys33/59	–	CK2	Promotion	–	22
Cullin 3 E3 ligase	BCL2	–	Thr69	PKM2	Inhibition	Tumor promotion	41
Cullin 3 E3 ligase	NPR1	–	Ser11/15	–	Promotion	Regulation of plant immunity	42
Cullin 3-based KLHL20 E3 Ligase	ULK1	–	Ser1042/Thr1046	–	Promotion	Regulation of autophagy	43
Cullin 4A-based DDB1E3 ligase	CHK1	Lys180/244/313/436	Ser317/345	ATR	Promotion	Tumor suppression	44
Cullin 4A E3 ligase	PYGO2	–	Ser48	AKT	Inhibition	Tumor promotion	45
Cullin 5-based SOCS6 E3 ligase	p130Cas	–	–	SRC	Promotion	Tumor suppression	21

–Not applicable.