Table 2.
Summary of the crosstalk between phosphorylation and ubiquitination and its biological function when phosphorylation exits in CRLs.
| CRL | Substrate | Ubiquitinated site | Phosphorylated site | Kinase | How phosphorylation affects interaction between substrates and receptors | Biological function | Ref. |
|---|---|---|---|---|---|---|---|
| Cullin 1-based SCF E3 ligase | – | – | Thr31/Ser557 | AKT | Promotion | Regulation of cell cycle | 46 |
| Cullin 1-based FBW7 E3 ligase | – | – | Thr205 | ERK | – | Tumor promotion | 47 |
| Cullin 3-based SPOP E3 ligase | PDL1 | – | – | CDK4 | Promotion | Tumor promotion | 24 |
| Cullin 3-based KEAP1 E3 ligase | NRF2 | – | Ser53 | – | Inhibition | Response to oxidative stresses | 25 |
| Cullin 3-based KLHL3 E3 ligase | WNK4 | Lys157 | Ser433 | PKCα/PKCβ | Inhibition | Regulation of hypertension and cardiovascular disease | 48 |
| Cullin 4-based CDT2 E3 ligase | FBXO11 | Lys197 | Thr464 | CDK | Inhibition | Regulation of cell cycle | 31 |
| Cullin 5-based VACM-1 E3 ligase | – | – | Ser730 | PKA/PKC | The phosphorylated receptor is induced to be ubiquitinated | Tumor promotion | 49 |
–Not applicable.