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Empirical rules for predicting oral availability and toxicity of a compound.
| Properties | Oral availability | Toxicity | Pfizer 3/75 rules |
|---|---|---|---|
| Lipinski rules | Veber rules | ||
| MW | ≤500 | – | – |
| LogP | ≤5 | – | ≤3 |
| HBA | ≤10 | – | – |
| HBD | ≤5 | – | – |
| TPSA | – | ≤140 | ≥75 |
| RB | – | ≤10 |
MW: Molecular weight, LogP: octanol/water partition coefficient, HBA: Hydrogen Bond Acceptor, HBD: Hydrogen Bond Donor, TPSA: Topological Polar Surface Area and RB: Rotatable Bond.
