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. 2021 Feb 5;11:598118. doi: 10.3389/fgene.2020.598118

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Copyright © 2021 van de Stolpe, Verhaegh, Blay, Ma, Pauwels, Pegram, Prenen, De Ruysscher, Saba, Slovin, Willard-Gallo and Husain.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis on data from GSE80667, described in Fertig et al. (2016). HaCaT premalignant keratinocyte cell line (mock), with overexpressed wild-type EGFR (EGFR),or activating mutation in HRAS (HRAS^V12D) (HRAS) or PIK3CA (PIK3CA^H1047R) (PIK3CA) genes; treated for 24 h with cetuximab, gefitinib, or afatinib. Measured FOXO activity score per analyzed sample, presented on a log2odds scale; PI3K pathway activity is the inverse of the FOXO activity score.