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Respective optimal applications of siRNA, CRISPR/Cas9, and ASOs based on lncRNA intracellular localization. siRNAs are appropriate for cytoplasmic lncRNAs, ASOs for nuclear lncRNAs, and CRISPR/Cas9 for dual-localized lncRNAs or those with unknown cellular localization. CRISPR, clustered regularly interspaced short palindromic repeats; Cas9, CRISPR associated protein 9; sgRNA, single guide RNA; ASO, antisense oligonucleotide; RISC, RNA-induced silencing complex.
