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(A) Optimization of ring A and B in compound 9 resulted in the generation of TSR-011 and (B) X-ray cocrystal structure of compound 11 in ALK (PDB ID: 4FOD; 2.0 Å). The kinase is illustrated with green ribbons, and the hydrogen bonds are depicted in black dashed lines. Compound atoms are in different colors: C, orange; N, blue; O, red; F, light cyan.
