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Hmox1 (A), Hmox2 (B) mRNA and HMOX1 (C, F), HMOX2 (D, F), NRF2 (E, F) proteins expression in gastric mucosa of rats pretreated i.g. with vehicle or BW-CO-111 (0.1 mg/kg) and administered 30 min later with aspirin (125 mg/kg, i.g.). Results are mean ± SEM of 5 rats per experimental group. Red line indicates baseline value of mRNA expression in healthy gastric mucosa without any treatments. ∗P < 0.05 compared with healthy gastric mucosa.
