Figure 9.
Effect of pretreatment with vehicle or BW-CO-111 (0.1 mg/kg) administered 30 min prior aspirin (125 mg/kg, i.g.) on alterations in Cox1 (A), Cox2 (B) mRNA, COX1 (C, E), COX2 (D, E) proteins expression and the mucosal concentrations of prostaglandin E2 (PGE2, F). Results are mean ± SEM of 5 rats per experimental group. Red line indicates baseline value of mRNA expression in healthy gastric mucosa without any treatments (Intact). ∗P < 0.05 compared with healthy gastric mucosa; ∗∗P < 0.05 compared with respective values obtained in vehicle-pretreated group.