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In vivo pharmacokinetics of free Cy5, RPMPC and HPMPC nanogels after the 1st intravenous injection (A) and (B) the 2nd intravenous injection in BALB/c mice. (C) The detection of immunoglobulin M (IgM) levels in vivo after the 1st injection. (D) The detection of immunoglobulin G (IgG) levels in vivo after the 2nd injection. The distribution of RPMPC and HPMPC nanogels in the main organs and tumors at (E) 24 h and (F) 48 h post-injection. n.s.: no significant difference.
