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. 2020 Nov 4;3(2):182–194. doi: 10.1016/j.cjco.2020.10.015

Figure 3.

Figure 3

(A and B) Representative fluorescent confocal images of [Dpr3(n-octanoyl),Lys19(sulfo-Cy5)]ghrelin(1-19); red), ghrelin (green), and natriuretic peptide type-B (BNP; magenta) in human cardiac tissue in the left atrium (LA) and left ventricle (LV). Nuclei were visualized with DAPI (blue). Graphs show linear regression analysis of quantified integrated densities with each dot representing an individual patient sample. (C) There was significant linear regression of [Dpr3(n-octanoyl),Lys19(sulfo-Cy5)]ghrelin(1-19) vs BNP (r = 0.5633; P = 0.0034) in the entire patient cohort (n = 25). (D) When data were disaggregated by region, a significant linear regression was found in the LA (r = 0.6751; P = 0.0029; n = 17) but not the LV (P = not significant [ns]; n = 8). (E) Ghrelin and BNP were correlated in the entire patient cohort (r = 0.5008; P = 0.0108; n = 25). (F) Linear regression analysis between ghrelin and BNP indicate correlations in the LV (r = 0.9152; P = 0.0014; n = 17) but not the LA (P = ns; n = 9). GHSR, growth hormone secretagogue receptor.