Fig. 2.

Predicted protein family distribution. Clusters of orthologous groups were identified in S. actuosus ISP-5337, S. sioyaensis B-5408, A. acidiphila B-2296, and E. coli K-12 MG-1655 by scanning the amino acid files using InterProScan [42]. The results from the InterProScan analysis were submitted to EggNOG [43] for annotation and classification of the protein families. The annotated protein families were plotted based on the percent of total predicted proteins per category. The number of proteins predicted to be involved in secondary metabolite biosynthesis (indicated by the red arrow) is 4 times as high in the Actinomycetes compared to the human pathogen Escherichia coli K-12 MG-1655.