Fig. 1.

Real-time semi-automatic analysis of parameters. Definition of the expansion start time, expansion time, blood flow decay time constant, AUC, maximal dilation rate, and the extended time constant. ΔFMD/ΔNMD, the magnitude in percentage change in peak diameter from baseline; expansion start time, the time from releasing the tourniquet or sublingual administration to reach the change in diameter; expansion time, the time from the start to reach the peak diameter; blood flow decay time constant, the blood flow decay time constant indicating the bloodstream in the process of change; AUC, the integrated response calculated as the area under the dilation curve during the maximum dilation period after change of diameter; maximal dilation rate, the maximal dilation rate is calculated as the maximum slope of the diameter dilation; the extended time constant, the extended time constant indicates the time to reach 63% of the peak diameter.