Table 1.

Plasma variables in YFP-Ptc^+/+ and YFP-Ptc^−/− fasted mice and high fat diet.

	YFP-Ptc+/+	YFP-Ptc−/−	YFP-Ptc+/+	YFP-Ptc−/−	YFP-Ptc+/+	YFP-Ptc−/−
	Chow diet				High fat dietΔ
	4 weeks post–Tx		32 weeks post–Tx		22 weeks post–Tx
Glucose (mg/dl)	97.8 ± 5.8	90.8 ± 7.5	99.0 ± 8.7	63.0 ± 7.5a	ND	ND
Insulin (ng/ml)	0.35 ± 0.08	0.13 ± 0.05a	1.09 ± 0.41	0.15 ± 0.04a	2.08 ± 0.24	0.15 ± 0.05c
Leptin (ng/ml)	0.31 ± 0.08	0.19 ± 0.04	14.8 ± 3.4	0.36 ± 0.21b	28.2 ± 4.9	2.4 ± 1.5c
NEFA (μmol/l)	1590 ± 83	1529 ± 91	1901 ± 180	1294 ± 78a	ND	ND
Adiponectin (ng/ml)	ND	ND	10822 ± 1230	12835 ± 1129	8457 ± 1061	10961 ± 881

Data are means ± SEM, n = 4–9/group.

^ap < 0.05.

^bp < 0.01.

^cp < 0.001 vs age-matched YFP-Ptc+/+ mice by Student's t-test. ^Δ12 weeks of high fat diet. ND, not determined.