A, Unadjusted incidence of nonsevere and severe acute toxic effects. Nonsevere toxic effects were those lower than grade 3, and severe toxic effects were those at grade 3 or higher. B, Relative incidence of severe toxic effects among patients who developed an acute adverse reaction. C, Unadjusted incidence of severe late toxic effects. D, Relative incidence of severe late toxic effects. CF indicates conventional fractionation; CVD, collagen vascular disease; MH, moderate hypofractionation; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; and UH, ultrahypofractionation.