Table 2. Unadjusted Incidence of Acute and Late Toxic Effects by Grade Over 12 Years, Stratified by Dose-Fractionated Radiotherapy Regimen.
| Toxic effect | No. (%) | ||
|---|---|---|---|
| Conventional fractionation | Moderate hypofractionation | Ultrahypofractionation | |
| Acute | |||
| Patients with missing toxic effects data, No. | 6 | 1 | 2 |
| Patients with available toxic effects data | |||
| Total patients, No. | 74 | 54 | 60 |
| Gradea | |||
| 0 | 7 (9.5) | 5 (9.3) | 26 (43.3) |
| 1 | 36 (48.6) | 28 (51.8) | 22 (36.7) |
| 2 | 27 (36.5) | 17 (31.5) | 11 (18.3) |
| 3 | 4 (5.4) | 4 (7.4) | 1 (1.7) |
| 4 | 0 | 0 | 0 |
| 5 | 0 | 0 | 0 |
| Late | |||
| Patients with missing toxic effects data, No. | 20 | 19 | 16 |
| Patients with available toxic effects data | |||
| Total patients, No. | 60 | 36 | 46 |
| Gradea | |||
| 0 | 14 (23.3) | 17 (47.2) | 24 (52.2) |
| 1 | 30 (50.0) | 13 (36.1) | 13 (28.3) |
| 2 | 11 (18.3) | 6 (16.7) | 8 (17.4) |
| 3 | 4 (6.7) | 0 | 1 (2.2) |
| 4 | 1 (1.7) | 0 | 0 |
| 5 | 0 | 0 | 0 |
a
Toxic effects were graded using the Common Terminology Criteria for Adverse Events, version 526 (grade range, 1-5, with 1 indicating a mild or asymptomatic event and 5 indicating death). Toxic effects with grades of 3 or higher were considered severe.