Figure 9.

Change in circulation times of tracer after inducing inflammation. In healthy mice (top row), anti-Ly6G SPIO tracer predominantly distributes in the organs of the RES including the liver, spleen, and bone marrow, at around 4-5 hours post-tracer administration. We observed a change in the circulation times of the tracer in myositis induced mice (bottom row). These mice showed prominent MPI signal from the ventricles of the heart around 4-5 hours of post-tracer administration indicative of longer circulation times of tracer post inflammation (RES: reticuloendothelial system; SPIO: superparamagnetic iron oxide).