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. 2021 Jan 29;18(6):1456–1464. doi: 10.7150/ijms.51256

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LY3214996 increased sorafenib inhibition of Huh7^R cell migration. (A and B) Wound healing assays were carried out to assess cell migration of Huh7^R cells treated with sorafenib, LY3214996, or the combination of the two for 12 h and 24 h. (C and D) Related proteins of tumor-cell migration (MMP-2 and MMP-9) were detected by western blot. (E) A proposed working model of how LY3214996 acts on the Ras/Raf/MAPK pathway to affect migration of Huh7^R cells. Data are expressed as mean ± SD of three independent experiments (* p < 0.05; **p < 0.01; ***p < 0.001).