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LY3214996 increases the anti-tumor effect by blocking Ras/Raf/MAPK pathway in Huh7R cells. (A) and (B) After incubation with sorafenib (12 µM), LY3214996 (1 µM), or combination for 24 h, cells were lysed, and the designated proteins of Ras/Raf/MAPK and PI3K/Akt pathways were detected by western blot analysis. Data expressed as mean ± SD of three independent experiments (*p<0.05; **p<0.01; ***p<0.001).
