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The function of ATF4 to regulate cancer cell biology. (A,B) Overexpression of ATF4 significantly promoted cancer cell growth (A, colony formation study) and invasion (B, Matrigel invasion assay) (p<0.05). (C) ATF4 overexpression in HBE cells did not significantly promote cell invasion (p>0.05). The experiments were repeated at least 3 times. The group of “ATF4” refers to the group with overexpression of ATF4 in A549 cells and HBE cells.
