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Regulation of Wnt/β-catenin signaling by ATF4. (A,B,) Overexpression of ATF4 significantly upregulated the expression of Wnt signaling molecules including β-catenin, MMP7 and cyclin D1. (C) Dual-luciferase assays showed that overexpression of ATF4 upregulated the activity of Wnt/β-catenin signaling (p<0.05). The group of “ATF4” refers to the group with overexpression of ATF4 in A549 cells. The experiments were repeated at least 3 times.
