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. 2021 Jan 18;17(2):635–650. doi: 10.7150/ijbs.52319

Figure 6.

Figure 6

ITGB1 is associated with DNA double-strand breaks (DNA-DSBs) induced by radiation. A and B. Representative images of γH2AX-positive nuclei in shITGB1 and ITGB1 overexpression groups at indicated times following irradiation. γH2AX signal in red, nuclear counterstaining with 4′,6-diamidino-2-phenylindole in blue. Scale bar: 50 µm. γH2AX-positive nuclei were counted in five different fields, each with at least 20 nuclei; the number is shown in relationship to the count in non-irradiated cells. Values represent the average of three independent experiments (right). C and D. Detection of γH2AX protein levels in shITGB1 and ITGB1 overexpression groups treated with or without irradiation (8 Gy).