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. 2021 Jan 14;17(2):574–588. doi: 10.7150/ijbs.52097

Figure 4.

Figure 4

Next-generation sequencing of the differential expression of transcripts of ovarian cancer cells with CA125 stimulation. (A) Distribution of the differentially expressed transcripts in the MA plot. Red dots represent upregulated DEGs, blue dots represent downregulated DEGs, and black dots represent nondifferentially expressed genes. The abscissa is log2 (FPKM), and the ordinate log2 (FC). (B) Statistical histogram of DEGs. (C) Hierarchical clustering analysis of DEGs. (D) Enrichment scatter diagram of KEGG analyses of DEGs. The vertical axis represents the pathway, the horizontal axis represents the rich factor, the size of the point represents the number of DEGs in the pathway, and the color of the point corresponds to different Q-values. (E) Schematic diagram of the FOXO pathway and the hypothesis of the mechanism by which CA125 enhances cell migration.