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. 2021 Jan 14;17(2):574–588. doi: 10.7150/ijbs.52097

Figure 8.

Figure 8

Anti-MSLN inhibited tumorigenesis and metastasis facilitated by CA125. (A) Schematic diagram of therapeutic strategies of anti-MSLN. (B) The therapeutic effect of anti-MSLN on tumor growth was monitored by consecutively measuring tumor volume. Individual tumor images (C) and lymphatic tissue images (D) were taken after the mice were sacrificed. (E) Representative micrographs of H&E staining (scale bars=100 µm). Red arrows indicate metastases. Green arrows indicate normal lymphatic vessels. Yellow arrows indicate the capillary. (F) Statistics of the percentages of positive lymphatic vessels in the inguinal and axillary lymphatic tissues. The results represent the mean ± SD. (G) LYVE-1 histochemical staining of inguinal and axillary lymphatic tissues. The red arrow shows the tumor cells in the lymphatic vessel (scale bars=100 µm). (H) Evan's blue lymphangiogram was used to evaluate tumor metastasis. Two-way ANOVA tests were used to compare the differences in tumor volume. The results represent the mean ± SD. **p<0.01.