Table 4.

Radiomics predicts the survival of head and neck cancer

Study	Tumor characteristics	Imaging modality	Outcome	Machine learning methods
Shen et al. 2020 108	NPC	MRI	PFS	LASSO
Xu et al. 2020 113	NPC	PET	PFS	/
Ouyang et al. 2017 114	NPC	MRI	PFS	/
Zhang et al. 2017 115	Advanced NPC	MRI	PFS	LASSO
Lv et al. 2019 53	NPC	PET	PFS	/
Peng et al. 2019 52	NPC	PET	DFS	Deep learning
Yuan et al. 2019 109	HNSCC	MRI	OS	LASSO
Ming et al. 2019 116	NPC	MRI	DFS, OS, LRFS, DMFS	LASSO
Mao et al. 2019 117	NPC	MRI	PFS	/
Chen et al. 2020 118	LC	CT	OS	LASSO
Folkert et al.2017 119	OC	PET	ACM, DM	Multiparameter logistic regression
Foley et al.2018 120	OC	PET	OS	/
Chen et al.2019 121	EC	PET	DFS, OS	Multivariate logistic regression
Xiong et al. 2017 122	EC	PET	PFS	SVM, RF
Feliciani et al. 2018 123	HNC	PET	PFS	LASSO
Liao et al. 2019 124	Oropharyngeal and hypopharyngeal cancer	PET	OS, PRFS, DFS	/
Lv et al. 2019 125	HNC	PET/CT	RFS, MFS, OS	/
Yang et al. 2019 126	Advanced NPC	MRI	PFS	LASSO
Leijenaar et al. 2015 127	OSCC	CT	OS	/
Agarwal et al. 2020 111	LC	CT	LFS	/
Zhong et al. 2020 128	T3N0M0 NPC	MRI	DFS	Deep learning
Parmar et al. 2015 110	HNC	CT	OS	Different machine-learning classifiers
Liu et al. 2020 112	HNSCC	PET	OS, DFS	/
Pan et al. 2019 130	Oral tongue cancer	CT	Survival time	PCA
Xie et al. 2020 129	HNC	PET	OS, DFS	LR, SVM, RF, XG boost classifier
Cozzi et al. 2019 131	HNC	CT	OS, PFS	/
Legar et al. 2018 132	HNC	CT	OS, LRC	Six machine learning algorithms
Sörensen et al. 2019 133	HNC	PET	OS	/
Haider et al. 2020 134	OSCC	PET	OS, PFS	/
Ou et al. 2017 135	HNC	CT	PFS, OS	PCA
Miller et al. 2019 136	OPSCC	CT	PFS	/
Mes et al. 2020 137	HNSCC	MRI	RFS, OS	/

OPSCC: Oropharyngeal Squamous Cell Carcinoma; RFS: Relapse-free survival; ACM: All-cause mortality; LFS: Laryngectomy free survival; PRFS: Primary relapse-free survival; RFS: Recurrence-free survival; MFS: Metastasis-free survival; LRC: Locoregional tumor control; DMFS: Disease distant metastasis-free survival; OC: Oropharyngeal carcinoma.