Figure 1.
Individual participant raw data showing translocator protein levels (estimated using total distribution volume [VT]) in participants with first-episode psychosis or schizophrenia and healthy control subjects, from all five included studies, from frontal cortex (FC), temporal cortex (TC), and hippocampus (HIP). The black bars denote the group means. For each region, subjects’ VT values have been Z-scored within study, and within genotype, in order to produce the pooled plots of all high-affinity binders (HABs) and mixed-affinity binders (MABs). For this reason, HABs and MABs have the same mean (set to zero) in the right-hand panels. Included studies: Bloomfield et al. (22); Collste et al. (23); Coughlin et al. (24); Hafizi et al. (25); Kenk et al. (26).