Figure 2.

Standardized difference in translocator protein levels (estimated using total distribution volume [V_T]) between patients with psychosis and healthy control subjects. The posterior distribution for each study-specific difference in V_T (ΔV_T) estimate (random slopes) from the linear mixed model is presented. The black circle denotes the posterior mean, and the thick line denotes the 95% credible interval; these are also presented in text next to the plots. The cross denotes the patient–control mean difference in raw data (together with its 95% credible interval) without performing linear mixed-effects modeling. Hence, the difference between the dot and the cross displays the model shrinkage toward the mean. The overall ΔV_T estimate suggests that patients with schizophrenia or first-episode psychosis have lower levels of translocator protein compared with healthy control subjects. Included studies: Bloomfield et al. (22); Collste et al. (23); Coughlin et al. (24); Hafizi et al. (25); Kenk et al. (26).