Skip to main content
. Author manuscript; available in PMC: 2021 Feb 19.
Published in final edited form as: Oral Oncol. 2019 Jul 12;96:77–88. doi: 10.1016/j.oraloncology.2019.06.032

Figure 2. Interrogation of the 12-chemokine gene expression signature in SCCHN tumors by HPV-status.

Figure 2.

(A) Histogram of distribution of TCIP-L (blue), TCIP-intermediate (gray) and TCIP-H (orange) phenotypes in HPV-negative versus HPV-positive SCCHN tumors across the CHGC and TCGA cohorts. (B) CD8 gene expression box-plot analysis in the CHGC SCCHN tumors in all TCIPs, TCIP-H only and TCIP-L only tumors based on HPV-status. The degree of CD8+ T-cell infiltration was significantly higher in HPV-positive compared to HPV-negative tumors in the categories of all TCIP tumors (Mann-Whitney test, p=2×10−8) and in TCIP-H tumors (Mann-Whitney, p=0.0001), but was insignificant for TCIP-L tumors (Mann-Whitney, p=0.39).