Table 1. Expression of Folate Receptor Subtypes FRα, FRβ, FRγ Based on Normalized RNA Expression (NX) Data from Three Different Sources: Internally Generated Human Protein Atlas (HPA) RNA-seq Data, RNA-seq Data from the Genotype-Tissue Expression (GTEx) Project, and CAGE Data from FANTOM5 Projecta.
| organ | FRα14 | FRβ15 | FRγ16 |
|---|---|---|---|
| brain | very high | low | very low |
| eye | low | moderate | very low |
| endocrine tissues | very low | moderate | very low |
| lung | moderate | low | moderate |
| proximal digestive tract | high | moderate | very low |
| gastrointestinal tract | low | moderate | very low |
| liver and gallbladder | very low | moderate | very low |
| pancreas | very low | low | low |
| kidney and urinary bladder | moderate | moderate | low |
| male tissues | low | moderate | very low |
| female tissues | moderate | very high | low |
| muscle tissues | very low | moderate | low |
| adipose and soft tissue | very low | very high | low |
| skin | very low | low | very low |
| bone marrow and lymphoid tissues | very low | moderate | moderate |
| Blood | very low | moderate | very high |
a
The protein expression was evidenced by three sources: UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence).17