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. 2021 Jan 25;23(4):228. doi: 10.3892/mmr.2021.11867

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Copyright © Cheng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 8. — Overexpression of DUSP4 reverses the inductive effect of miR-429 overexpression on the expression of apoptosis-related proteins in resistant CRC cells treated with nintedanib. (A) Western blotting of apoptosis-related proteins in resistant CRC cells treated with nintedanib. The expression levels of apoptosis-related proteins, including (B) Bcl-2, (C) Bax, (D) cleaved caspase-3 and (E) caspase-3 in CRC cells were detected by western blotting. **P<0.01, ***P<0.001 vs. SW480; ^#P<0.05, ^##P<0.01, ^###P<0.001 vs. SW480-R; ^∆∆P<0.01, ^∆∆∆P<0.001 vs. SW480-R mimic NC; ^$P<0.05 vs. SW480-R miR-429 mimic + Oe-NC. CRC, colorectal cancer; miR-429, microRNA-429; DUSP4, dual specificity protein phosphatase 4; NC, negative control; Oe-DUSP4, DUSP4 overexpression plasmid; Oe-NC, NC overexpression plasmid; -R, resistant to nintedanib.