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. 2021 Jan 25;23(4):228. doi: 10.3892/mmr.2021.11867

Figure 9.

Figure 9.

Overexpression of DUSP4 reverses the inductive effect of miR-429 overexpression on the expression of JNK-related proteins in resistant colorectal cancer cells treated with nintedanib. (A) Western blotting of JNK-related proteins. Expression levels of JNK-related proteins, including (B) p-JNK, (C) JNK, (D) p/t-JNK, (E) c-Jun and (F) MDR1 were detected by western blotting. *P<0.05, **P<0.01, ***P<0.001 vs. SW480; #P<0.05, ###P<0.001 vs. SW480-R; ∆∆∆P<0.001 vs. SW480-R mimic NC; $$$P<0.001 vs. SW480-R miR-429 mimic + Oe-NC. miR-429, microRNA-429; DUSP4, dual specificity protein phosphatase 4; NC, negative control; Oe-DUSP4, DUSP4 overexpression plasmid; Oe-NC, NC overexpression plasmid; -R, resistant to nintedanib; p-, phosphorylated; t-, total; MDR1, multidrug resistance protein.